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CACNA1G/CACNA1H (AA 311-420) antibody (AbBy Fluor® 647)

This anti- antibody is a Rabbit Polyclonal antibody detecting in IF (cc), IF (p). Suitable for Rat.
Catalog No. ABIN1394478

Quick Overview for CACNA1G/CACNA1H (AA 311-420) antibody (AbBy Fluor® 647) (ABIN1394478)

Target

CACNA1G/CACNA1H

Reactivity

  • 15
  • 1
  • 1
Rat

Host

  • 15
Rabbit

Clonality

  • 15
Polyclonal

Conjugate

  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
AbBy Fluor® 647

Application

  • 12
  • 12
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Binding Specificity

    • 14
    • 1
    AA 311-420

    Cross-Reactivity

    Rat

    Predicted Reactivity

    Human,Mouse,Dog,Cow

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from CACNA1G + CACNA1H

    Isotype

    IgG
  • Application Notes

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    CACNA1G/CACNA1H

    Alternative Name

    CACNA1G + CACNA1H

    Background

    Synonyms: Cav3.1c, Low voltage activated calcium channel alpha1 3.2 subunit, NBR13, Voltage dependent T type calcium channel subunit alpha 1G, Voltage dependent T type calcium channel subunit alpha 1H, Voltage gated calcium channel subunit alpha Cav3.1, Voltage gated calcium channel subunit alpha Cav3.2, CAC1G_HUMAN, CAC1H_HUMAN.

    Background: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. There are 2 isoforms of CACNA1H and 14 isoforms if CACNA1G, produced by alternative splicing.

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