Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) antibody (Alexa Fluor 350)

Details for Product No. ABIN1395321
Antigen
  • ACCN2
  • ASIC
  • BNaC2
  • Accn2
  • ASIC1
  • AI843610
  • ASIC1a
  • B530003N02Rik
  • acid sensing ion channel subunit 1
  • acid-sensing (proton-gated) ion channel 1
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
  • ASIC1
  • Asic1
  • asic1
  • SMARCD1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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Clonality
Polyclonal
Conjugate
Alexa Fluor 350
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Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
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Options
Immunogen KLH conjugated synthetic peptide derived from human ACCN2/ASIC1
Isotype IgG
Purification Purified by Protein A.
Antigen
Alternative Name Accn2 (ACCN2 Antibody Abstract)
Background

Acid sensing ion channel ASIC1 is present in brain as a 4.3-kb transcript with localization to rat dorsal root ganglia. In situ hybridization of rat brain suggests that ASIC1 is most abundant in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei and cerebellum. ASIC1 and H+-gated currents may contribute to the development of fear and anxiety. ASIC2, also designated amiloride-sensitive cation channel 1, neuronal (ACCN1), mammalian degenerin, BNAC1 (MDEG) and brain Na+ channel 1, mediates the normal detection of light touch. ASIC2 mRNA is abundant in brain, specifically in neurons. ASIC2 is expressed as 2.7- and 3.7-kb transcripts in brain and spinal cord tissues. ASIC3, also designated SLNAC1 and TNaC1, mediates detection of lasting pH changes and is involved in modulating moderate- to high-intensity pain sensation. ASIC4, also designated ACCN4 and BNAC4, is abundant in pituitary gland and is also present in the inner ear.

Subcellular location: Extracellular

Synonyms: ASIC1, ACCN2, ACCN2_HUMAN, Acid sensing ion channel 1, Acid sensing ion channel 1a protein, Acid sensing ion channel, Acid-sensing ion channel 1, AI843610, Amiloride sensitive cation channel 2 neuronal, Amiloride-sensitive cation channel 2, ASIC, ASIC1, ASIC1A, B530003N02Rik, BNAC2, Brain sodium channel 2, Cation channel amiloride sensitive neuronal 2, hBNaC2, neuronal.

Application Notes IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months
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