SLC51B antibody (FITC)

Catalog No. ABIN1396087

This Rabbit Polyclonal antibody specifically detects SLC51B in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SLC51B antibody (FITC) (ABIN1396087)

Target: SLC51B (OSTBETA) (Organic Solute Transporter beta (OSTBETA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC51B antibody is conjugated to FITC

Application: Western Blotting (WB)

Product Details anti-SLC51B Antibody (FITC)

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human OST-beta

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SLC51B

Target: SLC51B (OSTBETA) (Organic Solute Transporter beta (OSTBETA))

Alternative Name: Ost-beta

Background:

Synonyms: organic solute transporter beta Ostbeta, Organic solute transporter subunit beta, Ostbeta, Ost beta, OST-beta, OSTB, OSTB_HUMAN.

Background: The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum.

Gene ID: 123264

Pathways: Regulation of Carbohydrate Metabolic Process