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TGFB1 antibody (Transforming Growth Factor, beta 1) AA 101-200 (FITC) Primary Antibody

TGFB1 Reactivity: Human, Mouse IF (cc), IF (p) Host: Rabbit Polyclonal FITC
Catalog No. ABIN1397005
$476.30
Plus shipping costs $45.00
100 μL
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Delivery in 11 to 16 Business Days
  • Target See all TGFB1 Antibodies
    TGFB1
    Binding Specificity
    • 73
    • 17
    • 16
    • 15
    • 14
    • 10
    • 9
    • 8
    • 8
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 101-200
    Reactivity
    • 199
    • 104
    • 57
    • 25
    • 21
    • 16
    • 15
    • 13
    • 11
    • 10
    • 9
    • 7
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 227
    • 50
    • 3
    • 1
    • 1
    • 1
    Rabbit
    Clonality
    • 229
    • 52
    Polyclonal
    Conjugate
    • 117
    • 36
    • 28
    • 14
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 2
    • 1
    This TGFB1 antibody is conjugated to FITC
    Application
    • 159
    • 93
    • 79
    • 78
    • 77
    • 46
    • 38
    • 38
    • 36
    • 26
    • 21
    • 11
    • 9
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Specificity
    The antibody targets the Latency-associated peptide (LAP), which is a cleavage product of the Transforming growth factor beta-1 proprotein (TGFB1)
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TGF beta 1/LAP
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C/-80 °C
    Storage Comment
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Expiry Date
    12 months
  • Target
    TGFB1
    Alternative Name
    TGFB1 (TGFB1 Products)
    Synonyms
    CED, DPD1, LAP, TGFB, TGFbeta, TGF-beta, TGF-BETA-1, TGF-beta5, ced, dpd1, lap, tgf-beta, tgfb, tgfb5, tgfbeta, TGF-beta1, TGFbeta1, Tgfb, Tgfb-1, ai39657, tgfb1, wu:fb13a07, xx:ai39657, TGFB1, csd, cdb1, cdg2, csd1, csd2, csd3, ebmd, lcd1, bigh3, cdgg1, betaig-h3, TGFB4, transforming growth factor beta 1, transforming growth factor beta-1, transforming growth factor beta 1 L homeolog, transforming growth factor, beta 1, transforming growth factor, beta 1a, transforming growth factor beta induced L homeolog, TGFB1, Tgfb1, tgfb1.L, tgfb1a, tgfbi.L
    Background

    Latency-associated peptide: Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia (Probable). Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1.

    Subcellular location: Secreted, Extracellular matrix

    Synonyms: Transforming growth factor beta-1 proprotein, CED, LAP, DPD1, TGFB, TGFbeta, TGF-beta-1, TGFB1

    Gene ID
    UniProt
    P01137
    Pathways
    EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints
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