RTN4IP1 antibody (AA 111-210) (FITC)

Catalog No. ABIN1398482

The Rabbit Polyclonal anti-RTN4IP1 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect RTN4IP1 in samples from Mouse.

Quick Overview for RTN4IP1 antibody (AA 111-210) (FITC) (ABIN1398482)

Target: RTN4IP1 (Reticulon 4 Interacting Protein 1 (RTN4IP1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RTN4IP1 antibody is conjugated to FITC

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-RTN4IP1 Antibody (FITC)

Binding Specificity: AA 111-210

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NIMP/RTN4IP1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RTN4IP1

Target: RTN4IP1 (Reticulon 4 Interacting Protein 1 (RTN4IP1))

Alternative Name: NIMP

Background:

Synonyms: mitochondrial, NIMP, NOGO interacting mitochondrial protein, NOGO-interacting mitochondrial protein, Reticulon 4 interacting protein 1, Reticulon 4 interacting protein 1, mitochondrial, Reticulon-4-interacting protein 1, RT4I1_HUMAN, Rtn4ip1, NIMP/RTN4IP1.

Background: Appears to be a potent inhibitor of regeneration following spinal cord injury.Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells, and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NIMP (NOGO-interacting mitochondrial protein), also known as RTN4IP1 (Reticulon-4-interacting protein 1), is a 396 amino acid mitochondrial protein that contains a C-terminal oxidoreductaselike domain and numerous sites for phosphorylation. NIMP is expressed in mitochondrial-rich tissue such as kidney, heart, skeletal muscle and specific regions within the nervous system. Through interaction with Nogo, it is likely that NIMP plays a role in Nogo-induced inhibition of neurite growth. There are three isoforms of NIMP that are produced as a result of alternative splicing events.

Gene ID: 84816