C17orf49 antibody (Biotin)

Catalog No. ABIN1403815

This Rabbit Polyclonal antibody specifically detects C17orf49 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for C17orf49 antibody (Biotin) (ABIN1403815)

Target: C17orf49 (Chromosome 17 Open Reading Frame 49 (C17orf49))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C17orf49 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-C17orf49 Antibody (Biotin)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C17orf49

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for C17orf49

Target: C17orf49 (Chromosome 17 Open Reading Frame 49 (C17orf49))

Alternative Name: C17orf49

Background:

Synonyms: Bap18, BAP18_HUMAN, BPTF-associated protein of 18 kDa, Chromatin complexes subunit BAP18, Chromosome 17 open reading frame 49, Hypothetical protein LOC124944, MGC49942, Uncharacterized potential DNA binding protein C17orf49.

Background: C17orf49 is a 172 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Gene ID: 124944