DOK6 antibody (AA 1-100) (Cy3)

Catalog No. ABIN1406955

This anti-DOK6 antibody is a Rabbit Polyclonal antibody detecting DOK6 in WB, IF (cc) and IF (p). Suitable for Human.

Quick Overview for DOK6 antibody (AA 1-100) (Cy3) (ABIN1406955)

Target: DOK6 (Docking Protein 6 (DOK6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOK6 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-DOK6 Antibody (Cy3)

Binding Specificity: AA 1-100

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DOK6

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DOK6

Target: DOK6 (Docking Protein 6 (DOK6))

Alternative Name: DOK6

Background:

Synonyms: Docking protein 5, Docking protein 5 like, Docking protein 6, DOK 6, DOK6, DOK-6, DOK5, DOK 5, DOK-5, DOK5L, Downstream of tyrosine kinase 6, HsT3226, MGC20785, Protein dok 5, DOK6_HUMAN.

Background: The downstream of kinase family (Dok-1-7) are members of a class of docking? proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.