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ATXN7 antibody (AA 301-400) (HRP)

ATXN7 Reactivity: Mouse, Rat WB, ELISA, IHC (fro), IHC (p) Host: Rabbit Polyclonal HRP
Catalog No. ABIN1408454
  • Target See all ATXN7 Antibodies
    ATXN7 (Ataxin 7 (ATXN7))
    Binding Specificity
    • 14
    • 7
    • 7
    • 6
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 301-400
    Reactivity
    • 34
    • 26
    • 18
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Mouse, Rat
    Host
    • 47
    • 1
    Rabbit
    Clonality
    • 47
    • 1
    Polyclonal
    Conjugate
    • 15
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This ATXN7 antibody is conjugated to HRP
    Application
    • 37
    • 22
    • 13
    • 13
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Mouse, Rat
    Predicted Reactivity
    Human,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Ataxin 7
    Isotype
    IgG
    Top Product
    Discover our top product ATXN7 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handling Advice
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    ATXN7 (Ataxin 7 (ATXN7))
    Alternative Name
    Ataxin 7 (ATXN7 Products)
    Synonyms
    MGC82940 antibody, ADCAII antibody, OPCA3 antibody, SCA7 antibody, A430107N12Rik antibody, AI627028 antibody, Sca7 antibody, ataxin-7 antibody, RGD1562692 antibody, ataxin 7 L homeolog antibody, ataxin 7 antibody, atxn7.L antibody, atxn7 antibody, ATXN7 antibody, Atxn7 antibody
    Background

    Synonyms: Ataxin7, Ataxin-7, ADCAII, ATXN 7, OPCA III, OPCA3, SCA 7, SCA7, Spinocerebellar Ataxia 7, Spinocerebellar ataxia type 7 protein, ATX7_HUMAN.

    Background: The human ataxin-7 gene, also known as spinocerebellar ataxia 7 or SCA7, maps to chromosome 3p13-p12, has a 2,727-bp open reading frame, and encodes a 892 amino acid protein containing a nuclear localization signal and a polyglutamine tract (1,2). SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product (3,4). Ataxin-7 is expressed within neurons both affected and unaffected in SCA7 pathology with subcellular localization being variable depending upon the neuronal subtype (5). Polyglutamine expanded in ataxin-7 may carry out its pathogenic effects in the nucleus by altering the matrix-associated nuclear structure and/or by disrupting nucleolar function (6).

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