Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

ATXN7 Products

(Ataxin 7 (ATXN7))

Categories

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured ATXN7 Categories

ATXN7 Antibodies

High quality antibodies with extensive validation data.

Recommended ATXN7 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7144797
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (2)
Cat. No. ABIN6260150
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7254688
Quantity 200 μL
Datasheet Datasheet

Recommended ATXN7 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3136672
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our ATXN7 products

Fiszer, Wroblewska, Nowak, Krzyzosiak: "Mutant CAG Repeats Effectively Targeted by RNA Interference in SCA7 Cells." in: Genes, Vol. 7, Issue 12, (2016) (PubMed).

Mu, Lin, Chen, Sung, Bai, Jow: "The perinatal outcomes of asymptomatic isolated single umbilical artery in full-term neonates." in: Pediatrics and neonatology, Vol. 49, Issue 6, pp. 230-3, (2009) (PubMed).

Yvert, Lindenberg, Picaud, Landwehrmeyer, Sahel, Mandel: "Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice." in: Human molecular genetics, Vol. 9, Issue 17, pp. 2491-506, (2000) (PubMed).

Cancel, Duyckaerts, Holmberg, Zander, Yvert, Lebre, Ruberg, Faucheux, Agid, Hirsch, Brice: "Distribution of ataxin-7 in normal human brain and retina." in: Brain : a journal of neurology, Vol. 123 Pt 12, pp. 2519-30, (2000) (PubMed).

Synonyms and alternative names related to ATXN7

ataxin 7 L homeolog (atxn7.L), ataxin 7 (atxn7), ataxin 7 (ATXN7), ataxin 7 (Atxn7), A430107N12Rik, ADCAII, AI627028, ataxin-7, MGC82940, OPCA3, RGD1562692, SCA7, Sca7

Protein level used designations for ATXN7

  • ataxin 7
  • ataxin-7
  • spinocerebellar ataxia type 7 protein
  • spinocerebellar ataxia 7 homolog
  • spinocerebellar ataxia type 7 protein homolog
You are here:
Support