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Complexin 1 antibody (AA 31-100) (Cy5.5)

The Rabbit Polyclonal anti-Complexin 1 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect Complexin 1 in samples from Mouse and Rat.
Catalog No. ABIN1408589

Quick Overview for Complexin 1 antibody (AA 31-100) (Cy5.5) (ABIN1408589)

Target

See all Complexin 1 (CPLX1) Antibodies
Complexin 1 (CPLX1)

Reactivity

  • 33
  • 24
  • 22
Mouse, Rat

Host

  • 47
  • 1
  • 1
Rabbit

Clonality

  • 49
Polyclonal

Conjugate

  • 17
  • 5
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Complexin 1 antibody is conjugated to Cy5.5

Application

  • 32
  • 19
  • 16
  • 12
  • 12
  • 6
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Binding Specificity

    • 16
    • 14
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 31-100

    Cross-Reactivity

    Mouse, Rat

    Predicted Reactivity

    Human,Cow,Pig,Chicken

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human CPLX1

    Isotype

    IgG
  • Application Notes

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    Complexin 1 (CPLX1)

    Alternative Name

    CPLX1

    Background

    Synonyms: complexin 1, Complexin I, Complexin-1, CPLX1, CPLX1_HUMAN, CPX I, CPX-I, CPX1, Synaphin 2, Synaphin-2, 921-S.

    Background: Complexin 1 and Complexin 2, also designated Synaphin 1 and Synaphin 2, contain an a-helical middle domain of approximately 58 amino acids. Complexin 1 and Complexin 2 are expressed in presynaptic terminals of inhibitory and excitatory hippocampal neurons, respectively, and in cytoplasmic pools during early stages of development. Complexins promote SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) precomplex formation by binding to synaxin with its a-helical domain. Complexins are important regulators of transmitter release at a late step in calcium dependent neurotransmitter release or immediately after the calcium-triggering step of fast synchronous transmitter release and preceding vesicle fusion. Neurons lacking complexins show reduced transmitter release efficiency due to decreased calcium sensitivity of the synaptic secretion process. Complexin 2 may play a role in LTP (long term potentiation) following tetanic stimulation. A progressive loss of Complexin 2 occurs in the brains of mice carrying the Huntington disease mutation, an autosomal dominant neurodegenerative disorder. Changes in the neurotransmitter release might contribute to the motor, emotional and cognitive dysfunctions seen in these mice.

    Pathways

    Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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