RIMS3 antibody (AA 21-120) (Cy5.5)

Catalog No. ABIN1408697

The Rabbit Polyclonal anti-RIMS3 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect RIMS3 in samples from Human.

Quick Overview for RIMS3 antibody (AA 21-120) (Cy5.5) (ABIN1408697)

Target: RIMS3 (Regulating Synaptic Membrane Exocytosis 3 (RIMS3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIMS3 antibody is conjugated to Cy5.5

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-RIMS3 Antibody (Cy5.5)

Binding Specificity: AA 21-120

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Horse,Chicken,Rabbit,Zebrafish

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RIMS3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RIMS3

Target: RIMS3 (Regulating Synaptic Membrane Exocytosis 3 (RIMS3))

Alternative Name: RIMS3

Background:

Synonyms: NIM 3, NIM3, Rab 3 interacting molecule 3, Regulating synaptic membrane exocytosis 3, Regulating synaptic membrane exocytosis protein 3, RIMS 3, RIMS-3, RIM 3, RIM3, RIM3 gamma, RIMS3, RIMS3_HUMAN.

Background: Rab 3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis and functions in an inhibitory capacity, controlling the recruitment and pooling of secretory vesicles at the plasma membrane. The Rim (Rab 3 interacting molecule) family of proteins (Rim1, Rim2, Rim3 and Rim4) are multidomain adaptors that regulate Rab 3 activity and sub-sequent neurotransmitter release. Rim3, also known as RIMS3 (regulating synaptic membrane exocytosis 3) or NIM3, is a 308 amino acid member of the Rim family. Localized to the synapse and to cell junctions, Rim3 contains one C2 domain and is thought to play an important role in the regulation of synaptic membrane exocytosis. Rim3, a protein that may be phosphorylated upon DNA damage, is expressed throughout the body with highest levels present in brain tissue.

Gene ID: 9783

Pathways: Stem Cell Maintenance, Synaptic Vesicle Exocytosis