TOR1B antibody (AA 281-336) (HRP)

Catalog No. ABIN1409474

The Rabbit Polyclonal anti-TOR1B antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect TOR1B in samples from Mouse.

Quick Overview for TOR1B antibody (AA 281-336) (HRP) (ABIN1409474)

Target: TOR1B (Torsin Family 1, Member B (Torsin B) (TOR1B))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOR1B antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-TOR1B Antibody (HRP)

Binding Specificity: AA 281-336

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Torsin B

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TOR1B

Target: TOR1B (Torsin Family 1, Member B (Torsin B) (TOR1B))

Background:

Synonyms: DQ1, Tor1b, Torsin 1B, TOR1B, FKSG18, Torsin family 1 member B, TOR1B_HUMAN.

Background: TorsinB is a 336 amino acid protein that localizes to the lumen of endoplasmic reticulum and belongs to the Torsin family. Expressed in a variety of tissues with particularly high levels in adult brain, TorsinB is thought to function as a molecular chaperone that assists in the conformational folding of membrane and secreted proteins. Via its ability to regulate protein folding, TorsinB plays a key role in postnatal developmental events and is essential for proper neurological development. TorsinB contains two PKC (protein kinase C) phosphorylations sites, one ATP binding domain and several conserved cysteines and shares 69 % amino acid identity with TorsinA, a related family member. Defects in the gene encoding TorsinB are associated with torsion dystonia, an autosomal dominant neurological disorder that is characterized by debilitating muscle contractions throughout the body.