GPR143 antibody (AA 201-300) (Cy5.5)

Catalog No. ABIN1411235

The Rabbit Polyclonal anti-GPR143 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect GPR143 in samples from Human.

Quick Overview for GPR143 antibody (AA 201-300) (Cy5.5) (ABIN1411235)

Target: GPR143 (G Protein-Coupled Receptor 143 (GPR143))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR143 antibody is conjugated to Cy5.5

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-GPR143 Antibody (Cy5.5)

Binding Specificity: AA 201-300

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human OA1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GPR143

Target: GPR143 (G Protein-Coupled Receptor 143 (GPR143))

Alternative Name: OA1/GPR143

Background:

Synonyms: ALBINISM OCULAR TYPE I, G protein coupled receptor 143, G-protein coupled receptor 143, GP143_HUMAN, GPR143, MOA1, NETTLESHIP FALLS TYPE OCULAR ALBINISM, Ocular albinism type 1 protein, Ocular albinism type 1 protein homolog, Ocular albinism1 Nettleship Falls type.

Background: G protein-coupled receptors (GPRs or GPCRs), are members of the largest protein family and play a role in many different stimulus-response pathways. G-protein coupled receptors mediate extracellular signals into intracellular signals (G-protein activation). They respond to a great variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides. GPR143, also designated ocular albinism type 1 protein (OA1), is detected exclusively in pigment cells. OA1, which is a multi-pass membrane protein, is a melanosomal protein expressed primarily in pigment cells. Defects in the gene encoding for OA1 cause ocular albinism, an X-linked disorder mainly characterized by retinal hypopigmentation and visual impairment.