ALDH3A2 antibody (AA 101-200) (Cy3)

Catalog No. ABIN1411269

This anti-ALDH3A2 antibody is a Rabbit Polyclonal antibody detecting ALDH3A2 in WB, IF (cc) and IF (p). Suitable for Human.

Quick Overview for ALDH3A2 antibody (AA 101-200) (Cy3) (ABIN1411269)

Target: ALDH3A2 (Aldehyde Dehydrogenase 3 Family, Member A2 (ALDH3A2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALDH3A2 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-ALDH3A2 Antibody (Cy3)

Binding Specificity: AA 101-200

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ALDH3A2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ALDH3A2

Target: ALDH3A2 (Aldehyde Dehydrogenase 3 Family, Member A2 (ALDH3A2))

Alternative Name: ALDH3A2

Background:

Synonyms: Ahd 3, Ahd 3r, Ahd3, Ahd3 r, AL3A2_HUMAN, Aldehyde dehydrogenase 10, Aldehyde dehydrogenase 3, Aldehyde dehydrogenase 3 family, member A2, Aldehyde dehydrogenase family 3 member A2, Aldehyde dehydrogenase family 3, subfamily A2, Aldehyde dehydrogenase, family 3, subfamily A, member 2, ALDH10, Aldh3, ALDH3A2, Aldh4, Aldh4 r, Aldh4r, FALDH, Fatty aldehyde dehydrogenase, FLJ20851, Microsomal aldehyde dehydrogenase, msALDH, SLS.

Background: Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH3A2 (aldehyde dehydrogenase 3 family, member A2), also known as SLS, FALDH or ALDH10, is a 485 amino acid single-pass membrane protein that localizes to the cytoplasmic side of the endoplasmic reticulum and belongs to the aldehyde dehydrogenase family. Expressed in a variety of tissues, including liver, heart, lung, brain, kidney and placenta, ALDH3A2 catalyzes the NAD+-dependent oxidation of long-chain aliphatic aldehydes to fatty acids, a process that is necessary for detoxification and lipid metabolism. Defects in the gene encoding ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS), an autosomal recessive neurocutaneous disorder characterized by severe mental retardation, seizures and speech defects. Multiple isoforms of ALDH3A2 exist due to alternative splicing events.