HMX2 antibody (AA 122-200) (HRP)

Catalog No. ABIN1411604

The Rabbit Polyclonal anti-HMX2 antibody has been validated for ELISA, IHC (p) and IHC (fro). It is suitable to detect HMX2 in samples from Human.

Quick Overview for HMX2 antibody (AA 122-200) (HRP) (ABIN1411604)

Target: HMX2 (H6 Family Homeobox 2 (HMX2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMX2 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-HMX2 Antibody (HRP)

Binding Specificity: AA 122-200

Predicted Reactivity: Human,Mouse,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HMX2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HMX2

Target: HMX2 (H6 Family Homeobox 2 (HMX2))

Alternative Name: HMX2

Background:

Synonyms: H6 family homeo box 2, H6 family homeobox 2, H6 homeo box 2, H6L, HMX 2, HMX2 , HMX2_HUMAN , Homeo box H6 family 2, Homeo box protein H6 family member 2, Homeobox H6 family 2 , Homeobox protein H6 family member 2, Homeobox protein HMX2, Nkx5 2.

Background: The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. HMX2 (H6 family homeobox 2), also known as H6L or Nkx5-2, is a 273 amino acid nuclear protein that belongs to the HMX homeobox family and contains one homeobox DNA-binding domain. HMX2 functions as a transcription factor that assists in specification of neuronal cell types and is essential for proper development of hypothalamus and inner ear. Hemizygous deletions of the gene encoding HMX2 are thought to lead to vestibular dysfunction, inner ear malformations and congenital sensorineural hearing loss.