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KALRN antibody (AA 1401-1500) (Cy7)

KALRN Reactivity: Human IF (cc), IF (p) Host: Rabbit Polyclonal Cy7
Catalog No. ABIN1411650
  • Target See all KALRN Antibodies
    KALRN (Kalirin, RhoGEF Kinase (KALRN))
    Binding Specificity
    • 14
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    AA 1401-1500
    Reactivity
    • 34
    • 13
    • 13
    • 1
    Human
    Host
    • 33
    • 1
    Rabbit
    Clonality
    • 34
    Polyclonal
    Conjugate
    • 11
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KALRN antibody is conjugated to Cy7
    Application
    • 12
    • 12
    • 12
    • 8
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Pig,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human KALRN/Duo
    Isotype
    IgG
    Top Product
    Discover our top product KALRN Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    KALRN (Kalirin, RhoGEF Kinase (KALRN))
    Alternative Name
    KALRN/Duo (KALRN Products)
    Synonyms
    ARHGEF24 antibody, CHD5 antibody, CHDS5 antibody, DUET antibody, DUO antibody, HAPIP antibody, TRAD antibody, KALRN antibody, 2210407G14Rik antibody, AV235988 antibody, E530005C20Rik antibody, Gm539 antibody, Hapip antibody, Duo antibody, Kalirin antibody, kalirin RhoGEF kinase antibody, kalirin, RhoGEF kinase antibody, kalirin antibody, kalirin RhoGEF kinase L homeolog antibody, putative kalirin antibody, KALRN antibody, LOC460643 antibody, Kalrn antibody, kalrn antibody, kalrn.L antibody, LOC100473997 antibody, Smp_162970 antibody
    Background

    Synonyms: Duo, FLJ16443, HAPIP, Huntingtin associated protein interacting protein duo , Huntingtin-associated protein-interacting protein, Kalirin isoform 2, Kalirin, KALRN , KALRN_HUMAN , Protein Duo, RhoGEF kinase, Serine/threonine kinase with Dbl and pleckstrin homology domains , Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, TRAD.

    Background: HAP1 (huntingtin-associated protein 1) binds to huntingtin (1). Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington?s disease (HD) (2,3). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1). HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4,5). HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem (1). Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons (6). Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.

    Pathways
    Neurotrophin Signaling Pathway
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