LRRTM4 antibody (AA 135-250) (HRP)

Catalog No. ABIN1411754

The Rabbit Polyclonal anti-LRRTM4 antibody has been validated for ELISA, IHC (p) and IHC (fro). It is suitable to detect LRRTM4 in samples from Human.

Quick Overview for LRRTM4 antibody (AA 135-250) (HRP) (ABIN1411754)

Target: LRRTM4 (Leucine Rich Repeat Transmembrane Neuronal 4 (LRRTM4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRTM4 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-LRRTM4 Antibody (HRP)

Binding Specificity: AA 135-250

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LRRTM4

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for LRRTM4

Target: LRRTM4 (Leucine Rich Repeat Transmembrane Neuronal 4 (LRRTM4))

Alternative Name: LRRTM4

Background:

Synonyms: Leucine rich repeat transmembrane neuronal 4, Leucine rich repeat transmembrane neuronal 4 protein, Leucine rich repeat transmembrane neuronal protein 4, Leucine-rich repeat transmembrane neuronal 4 protein, Leucine-rich repeat transmembrane neuronal protein 4, LRRT4_HUMAN, Lrrtm4.

Background: The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic / horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. The LRRTM protein family plays a role in the regulation of various cellular events during nervous system development. Localizing predominantly to the nervous system, LRRTM family members are known to exhibit synaptogenic activity. LRRTM4 (leucine-rich repeat transmembrane neuronal protein 4) is a 590 amino acid member of the LRRTM protein family. Expressed in neuronal tissues, LRRTM4 may play a role in the development and maintenance of the vertebrate nervous system. A single-pass type I membrane protein, LRRTM4 contains 10 LRR repeats. LRRTM4 is expressed as two isoforms produced by alternative splicing.

Pathways: Synaptic Membrane