Mpped2/Brain Protein 239 (AA 101-200) antibody (Cy5.5)

Catalog No. ABIN1411811

The Rabbit Polyclonal anti- antibody has been validated for IF (cc) and IF (p). It is suitable to detect in samples from Human.

Quick Overview for Mpped2/Brain Protein 239 (AA 101-200) antibody (Cy5.5) (ABIN1411811)

Target: Mpped2/Brain Protein 239

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Cy5.5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details

Binding Specificity: AA 101-200

Predicted Reactivity: Human,Mouse,Rat,Cow,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MPPED2/Brain protein 239

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Mpped2/Brain Protein 239

Background:

Synonyms: 239FB, Brain protein 239, C11orf8, Chromosome 11 open reading frame 8, D11S302E, dJ1024C24.1, dJ873F21.1, FAM 1B, FAM1B, Fetal brain protein 239, Hs.46638, Metallophosphoesterase domain containing 2, Metallophosphoesterase domain containing protein 2, MPPED 2, MPPD2_HUMAN.

Background: MPPED2 (Metallophosphoesterase domain-containing protein 2), also known as C11orf8, FAM1B or 239FB, is a 294 amino acid protein. Expressed primarily in fetal brain tissue, MPPED2 is encoded by a gene that maps to chromosome 11. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4 % of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double stranded DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.