Glucose-6-Phosphate Dehydrogenase antibody (AA 351-450) (HRP)

Catalog No. ABIN1415061

This anti-Glucose-6-Phosphate Dehydrogenase antibody is a Rabbit Polyclonal antibody detecting Glucose-6-Phosphate Dehydrogenase in WB, ELISA, IHC (p) and IHC (fro). Suitable for Mouse.

Quick Overview for Glucose-6-Phosphate Dehydrogenase antibody (AA 351-450) (HRP) (ABIN1415061)

Target: Glucose-6-Phosphate Dehydrogenase (G6PD)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glucose-6-Phosphate Dehydrogenase antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Glucose-6-Phosphate Dehydrogenase Antibody (HRP)

Binding Specificity: AA 351-450

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Glucose 6 Phosphate Dehydrogenase

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Glucose-6-Phosphate Dehydrogenase

Target: Glucose-6-Phosphate Dehydrogenase (G6PD)

Alternative Name: Glucose 6 Phosphate Dehydrogenase

Background:

Synonyms: G6PD, G6PD_HUMAN, G6PD1, G6pdx, Glucose 6 phosphate 1 dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, MET19, POS10, Zwf1p.

Background: Defects in G6PD are the cause of chronic non-spherocytic hemolytic anemia (CNSHA) . Deficiency of G6PD is associated with hemolytic anemia in two different situations. First, in areas in which malaria has been endemic, G6PD-deficiency alleles have reached high frequencies (1 % to 50 %) and deficient individuals, though essentially asymptomatic in the steady state, have a high risk of acute hemolytic attacks. Secondly, sporadic cases of G6PD deficiency occur at a very low frequencies, and they usually present a more severe phenotype. Several types of CNSHA are recognized. Class-I variants are associated with severe NSHA, class-II have an activity <10 % of normal, class-III have an activity of 10 % to 60 % of normal, class-IV have near normal activity.

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones