AKAP5 antibody (AA 611-714) (HRP)

Catalog No. ABIN1415637

This anti-AKAP5 antibody is a Rabbit Polyclonal antibody detecting AKAP5 in WB, ELISA, IHC (fro) and IHC (p). Suitable for Rat.

Quick Overview for AKAP5 antibody (AA 611-714) (HRP) (ABIN1415637)

Target: AKAP5 (A Kinase (PRKA) Anchor Protein 5 (AKAP5))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKAP5 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-AKAP5 Antibody (HRP)

Binding Specificity: AA 611-714

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AKAP5

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for AKAP5

Target: AKAP5 (A Kinase (PRKA) Anchor Protein 5 (AKAP5))

Alternative Name: AKAP5

Target Type: Viral Protein

Background:

Synonyms: A kinase PRKA anchor protein 5, A kinase anchor protein 5, A kinase anchor protein 79 kDa, A kinase anchoring protein 75/79, A-kinase anchor protein 5, A-kinase anchor protein 79 kDa, AKAP 5, AKAP 75, AKAP 79, AKAP-5, Akap5, AKAP5_HUMAN, AKAP75, AKAP79, cAMP dependent protein kinase regulatory subunit II high affinity binding protein, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein, H21.

Background: The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates (1). Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. This family of proteins has been designated A-kinase anchoring proteins (AKAP) (1-3). Members of this family, including MAP2 (microtubule-associated protein 2), neuronally expressed AKAP 79 and AKAP 150, and the DNA binding AKAP 95, display differential tissue specificity and localization (4-6). Evidence suggests that AKAP 79 and AKAP 150 are both capable of anchoring PKA to postsynaptic densities (PSD), which are a network of proteins located on the internal surfaces of excitatory synapses.

Gene ID: 9495

UniProt: P24588

Pathways: cAMP Metabolic Process