APLP1 antibody (AA 1-100) (HRP)

Catalog No. ABIN1417120

This Rabbit Polyclonal antibody specifically detects APLP1 in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Mouse.

Quick Overview for APLP1 antibody (AA 1-100) (HRP) (ABIN1417120)

Target: APLP1 (Amyloid beta (A4) Precursor-Like Protein 1 (APLP1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APLP1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-APLP1 Antibody (HRP)

Binding Specificity: AA 1-100

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APLP1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for APLP1

Target: APLP1 (Amyloid beta (A4) Precursor-Like Protein 1 (APLP1))

Alternative Name: APLP1

Background:

Synonyms: AMYLOID BETA A4 PRECURSOR-LIKE PROTEIN 1, AMYLOID PRECURSOR-LIKE PROTEIN, Amyloid-like protein 1 precursor, APLP 1, APLP, APLP-1, Aplp1, APLP1_HUMAN, C30.

Background: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.

Gene ID: 333

Pathways: cAMP Metabolic Process