BAGE2 antibody (Cy5)

Catalog No. ABIN1418784

This anti-BAGE2 antibody is a Rabbit Polyclonal antibody detecting BAGE2 in IF (p). Suitable for Human.

Quick Overview for BAGE2 antibody (Cy5) (ABIN1418784)

Target: BAGE2 (B Melanoma Antigen Family, Member 2 (BAGE2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAGE2 antibody is conjugated to Cy5

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-BAGE2 Antibody (Cy5)

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BAGE2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BAGE2

Target: BAGE2 (B Melanoma Antigen Family, Member 2 (BAGE2))

Alternative Name: BAGE2

Background:

Synonyms: B melanoma antigen 2, B melanoma antigen family, member 2, Cancer/testis antigen 2.2, CT2.2, BAGE2_HUMAN.

Background: Members of the BAGE gene family encode antigens that are recognized by cytotoxic T lymphocytes and are also known as CT (cancer/testis) antigens. Generated by juxtacentromeric shuffling of the MLL3 gene, the ancestral BAGE gene was expanded by acrocentric exchanges and/or juxtacentromeric movements.Generally, BAGE proteins are silent in all normal tissues with the exception of testis. BAGE2 and BAGE 3 (B melanoma antigen 2 and 3, respectively), also known as Cancer/testis antigen 2.2 and 2.3 (respectively), are 109 amino acid secreted proteins that are expressed in 22 % of melanomas, lung and bladder carcinomas, and are also expressed in normal testis tissue. Like the genes encoding MAGE proteins, BAGE genes are most likely silenced by DNA methylation and/or chromatin compaction in normal tissues other than testis.