VGLL2 antibody (Cy7)

Catalog No. ABIN1419188

The Rabbit Polyclonal anti-VGLL2 antibody has been validated for WB and IF (p). It is suitable to detect VGLL2 in samples from Human, Mouse and Rat.

Quick Overview for VGLL2 antibody (Cy7) (ABIN1419188)

Target: VGLL2 (Vestigial Like 2 (VGLL2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VGLL2 antibody is conjugated to Cy7

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-VGLL2 Antibody (Cy7)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human VGLL2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for VGLL2

Target: VGLL2 (Vestigial Like 2 (VGLL2))

Alternative Name: VGLL2

Background:

Synonyms: Protein VITO1, Transcription cofactor vestigial like 2, Transcription cofactor vestigial like protein 2, Transcription cofactor vestigial-like protein 2, Vestigial like 2, Vestigial like 2 Drosophila, Vgl-2, VGL2, VGLL 2, Vgll2, VGLL2_HUMAN, VITO1.

Background: Vgl-2, also known as VITO-1, is a 317 amino acid protein that contains a domain through which it interacts with TEF-1, a protein that plays a role in controlling the expression of numerous genes. Specific to skeletal muscle, Vgl-2 is expressed highly in adult fast muscle and is expressed at lower levels in adult slow muscle and fetal skeletal muscle. During muscle differentiation, Vgl-2 mRNA levels increase and Vgl-2 translocates from the cytoplasm to the nucleus. Overexpression of Vgl-2 in MYOD-transfected 10T1/2 mouse embryonic fibroblasts increases expression of myosin heavy chain (MHC), which is a marker of terminal muscle differentiation. This evidence suggests that Vgl-2 is essential for muscle gene expression. There are two isoforms of Vgl-2 that are produced as a result of alternative splicing events.

Gene ID: 245806