PACRG antibody (Cy5.5)

Catalog No. ABIN1419727

This Rabbit Polyclonal antibody specifically detects PACRG in WB and IF (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PACRG antibody (Cy5.5) (ABIN1419727)

Target: PACRG (PARK2 Co-Regulated (PACRG))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PACRG antibody is conjugated to Cy5.5

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-PACRG Antibody (Cy5.5)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PACRG

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PACRG

Target: PACRG (PARK2 Co-Regulated (PACRG))

Alternative Name: PACRG

Background:

Synonyms: GLUP, Molecular chaperone/chaperonin binding protein, PARK 2 co regulated, PARK 2 coregulated, PARK2 co regulated, PARK2 coregulated, PARK2CRG, Parkin co regulated gene protein, Parkin Co-regulated Gene, Parkin coregulated gene protein, RP3 495O10.2, PACRG_HUMAN.

Background: The deduced 257 amino acid protein PACRG (Parkin co-regulated gene) shows potential links to the ubiquitin/proteasome system. PACRG and Parkin are attached in a head-to-head arrangement on opposite DNA strands and share a common 5' flanking promoter region. The PACRG gene maps to chromosome 6q26, Northern blot analysis detects PACRG expression in all tissues examined except placenta. Using a positional cloning strategy in 197 Vietnamese leprosy simplex families (i.e. families with two unaffected parents and one affected child), significant connections between leprosy and 17 markers in the 5' regulatory region that PARK2 and PACRG share were observed. Possession of two or more of the 17 risk alleles is highly predictive of leprosy.PACRG is a gene located very close to parkin, in reverse orientation on the chromosome. It is thought to be co-transcribed with parkin by a bi-directional promoter between the two genes.

Gene ID: 135138