MUL1 antibody (AA 45-95) (HRP)

Catalog No. ABIN1419742

This Rabbit Polyclonal antibody specifically detects MUL1 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MUL1 antibody (AA 45-95) (HRP) (ABIN1419742)

Target: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUL1 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-MUL1 Antibody (HRP)

Binding Specificity: AA 45-95

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MUL1/RNF218

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MUL1

Target: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Alternative Name: MUL1

Background:

Synonyms: E3 ubiquitin-protein ligase MUL1, C1orf166, E3 ubiquitin ligase, E3 ubiquitin protein ligase MUL1, GIDE, Growth inhibition and death E3 ligase, MAPL, Mitochondrial anchored protein ligase, Mitochondrial ubiquitin ligase activator of NFKB 1, MUL1, MULAN, Putative NF kappa B activating protein 266, RING finger protein 218, RNF218, RP23-25C1.10-002, MUL1_HUMAN.

Background: E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugatin.

Gene ID: 79594

UniProt: Q969V5

Pathways: Positive Regulation of Endopeptidase Activity