CD276 antibody (PE-Cy5.5)

Catalog No. ABIN1424423

The Rabbit Polyclonal anti-CD276 antibody has been validated for WB. It is suitable to detect CD276 in samples from Human, Mouse, Rat, Cow and Pig.

Quick Overview for CD276 antibody (PE-Cy5.5) (ABIN1424423)

Target: CD276

Reactivity: Human, Mouse, Rat, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD276 antibody is conjugated to PE-Cy5.5

Application: Western Blotting (WB)

Product Details anti-CD276 Antibody (PE-Cy5.5)

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CD276/B7H3

Isotype: IgG

Application Details

Application Notes: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CD276

Target: CD276

Alternative Name: CD276/B7H3

Background:

Synonyms: B7H3, B7-H3, B7RP-2, 4Ig-B7-H3, CD276 antigen, B7 homolog 3, Costimulatory molecule, CD276, PSEC0249, UNQ309/PRO352

Background: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

Molecular Weight: 57kDa

Gene ID: 80381

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints