DSCAM antibody (PE)

Catalog No. ABIN1426575

This anti-DSCAM antibody is a Rabbit Polyclonal antibody detecting DSCAM in FACS. Suitable for Human, Mouse and Rat.

Quick Overview for DSCAM antibody (PE) (ABIN1426575)

Target: DSCAM (Down Syndrome Cell Adhesion Molecule (DSCAM))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DSCAM antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-DSCAM Antibody (PE)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Dscam

Isotype: IgG

Application Details

Application Notes: FCM: 1:20-100
Optimal working dilution should be determined by the investigator.

Comment:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4 °C

Expiry Date: 12 months

Target Details for DSCAM

Target: DSCAM (Down Syndrome Cell Adhesion Molecule (DSCAM))

Alternative Name: Dscam

Background:

DSCAM is a cell adhesion molecule belonging to the immunoglobulin superfamily. It is predominantly expressed in brain and contains six Fibronectin type-III domains and ten Ig-like C2-type domains. In mice, DSCAM is responsible for regulating isoneuronal self-avoidance, the tendency for sister arbors to avoid crossing each other and to spread out proportionately over an area. Isoneuronal self-avoidance is important for proper terminal branching (arborization). In some cell types, DSCAM also mediates heteroneuronal self-avoidance, which is important for the regular spacing of cell bodies and the prevention of hyperfasciculation. In humans, two DSCAM isoforms exist due to alternative splicing. The long isoform (also known as CHD2-42) is a single pass type I membrane protein, while the short isoform (CHD2-52), which lacks the C-terminal transmembrane containing region (amino acids 1572-2012), is secreted.

Subcellular location: Extracellular

Synonyms: CHD2 42, CHD2 52, CHD2, Down syndrome cell adhesion molecule, DSCAM, DSCAM_HUMAN, human CHD2-52 down syndrome cell adhesion molecule 2, 9, OTTHUMP00000109193 2, SD11109p.

Pathways: Regulation of Cell Size