P2RY14 antibody (PE)

Catalog No. ABIN1429375

This Rabbit Polyclonal antibody specifically detects P2RY14 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for P2RY14 antibody (PE) (ABIN1429375)

Target: P2RY14 (Purinergic Receptor P2Y, G-Protein Coupled, 14 (P2RY14))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P2RY14 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-P2RY14 Antibody (PE)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human G-protein coupled receptor 105

Isotype: IgG

Application Details

Application Notes: FCM(1:20-100)

Comment:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4°C

Expiry Date: 12 months

Target Details for P2RY14

Target: P2RY14 (Purinergic Receptor P2Y, G-Protein Coupled, 14 (P2RY14))

Alternative Name: Gpr105

Background:

G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR105, also designated P2Y14, is widely expressed throughout many brain regions where it localizes to glial cells, and specifically co-localizes with astrocytes. GPR105 is upregulated when a tissue is immunologically challenged with lipopolysaccharide, leading to the theory that GPR105 may play an important role in modulating peripheral and neuroimmune function.

Subcellular location: Extracellular

Synonyms: A330108O13Rik, G protein coupled receptor for UDP-glucose, G protein-coupled receptor 105, G protein-coupled receptor VTR 15-20, G-protein coupled receptor 105, GPR105, KIAA0001, P2RY14, P2Y purinoceptor 14, P2Y14 receptor, P2Y14, P2Y14 receptor, P2Y14_HUMAN, Purinergic receptor P2Y G protein coupled 14, Similar to TYPE-1 Angiotensin II receptor, UDP-glucose receptor, GPCR GPR105.