Cullin 7 antibody (PE-Cy5.5)

Catalog No. ABIN1434570

This anti-Cullin 7 antibody is a Rabbit Polyclonal antibody detecting Cullin 7 in WB. Suitable for Human, Mouse, Rat, Cow and Dog.

Quick Overview for Cullin 7 antibody (PE-Cy5.5) (ABIN1434570)

Target: Cullin 7 (CUL7)

Reactivity: Human, Mouse, Rat, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cullin 7 antibody is conjugated to PE-Cy5.5

Application: Western Blotting (WB)

Product Details anti-Cullin 7 Antibody (PE-Cy5.5)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Cullin 7

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Cullin 7

Target: Cullin 7 (CUL7)

Alternative Name: Cullin 7

Background:

Synonyms: CUL-7, CUL7, CUL7_HUMAN, Cullin-7, dJ20C7.5, KIAA0076.

Background: Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity). Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity.Involvement in disease: Defects in CUL7 are the cause of 3M syndrome type 1 (3M1). An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies.

Molecular Weight: 191kDa

Gene ID: 9820

Pathways: ER-Nucleus Signaling