NHEDC2 antibody (PE-Cy5.5)

Catalog No. ABIN1437280

This Rabbit Polyclonal antibody specifically detects NHEDC2 in WB. It exhibits reactivity toward Human, Mouse, Rat and Dog.

Quick Overview for NHEDC2 antibody (PE-Cy5.5) (ABIN1437280)

Target: NHEDC2 (Na+/H+ Exchanger Domain Containing 2 (NHEDC2))

Reactivity: Human, Mouse, Rat, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NHEDC2 antibody is conjugated to PE-Cy5.5

Application: Western Blotting (WB)

Product Details anti-NHEDC2 Antibody (PE-Cy5.5)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NHEDC2

Isotype: IgG

Application Details

Application Notes: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NHEDC2

Target: NHEDC2 (Na+/H+ Exchanger Domain Containing 2 (NHEDC2))

Alternative Name: NHEDC2

Background:

Synonyms: NHA2, Mitochondrial Na+/H+ exchanger NHA2, Mitochondrial sodium/hydrogen exchanger NHA2, Na+/H+ exchanger like domain containing protein 2, Na+/H+ exchanger domain containing 2, NHE domain containing protein 2, NHE10, NHEDC 2, Sodium/hydrogen exchanger like domain containing protein 2, SL9B2_HUMAN.

Background: Na+/H+ exchangers (NHEs) catalyze the transport of Na+ in exchange for H+ across membranes in organisms and are required for numerous physiological processes. NHEDC2 (Na+/H+ exchanger-like domain-containing protein 2), also known as NHA2, is a 537 amino acid mitochondrial protein. NHEDC2 is involved in organelle volume homeostasis by catalyzing the exchange of protons for Na+ and Li+ across the inner mitochondrial membrane. Found in red blood cells, NHEDC2 is required for bone resorption activity and osteoclast differentiation. As a multi-pass membrane protein, NHEDC2 is expressed as two isoforms produced by alternative splicing events.

Molecular Weight: 57kDa

Gene ID: 133308

Pathways: Proton Transport