KPNB1 antibody

Catalog No. ABIN1449199

This Rat Monoclonal antibody specifically detects KPNB1 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for KPNB1 antibody (ABIN1449199)

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Reactivity: Human, Mouse, Rat

Host: Rat

Clonality: Monoclonal

Conjugate: This KPNB1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 1D7

Product Details anti-KPNB1 Antibody

Specificity: This antibody detects Importin β.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein G agarose

Immunogen: Recombinant full-length mouse importin beta

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for KPNB1

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Alternative Name: NTF97

Background: Importin ß (karyopherin ß/PTAC97) forms a complex with importin a that is required for classical import of proteins across the nuclear envelope through the nuclear pore complex. Importin a acts as a bridge between the nuclear localization sequence (NLS) and importin ß, while importin ß is the site of initial docking to the pore and is responsible for transport of the target protein into the nucleus. Inside the nucleus, Ran-GTP binds to importin ß, resulting in dissociation of the ternary complex, and importin a and ß are independently recycled back into the cytoplasm. Recently some NLS-containing proteins have been shown to bind directly to importin ß and enter the nucleus in an importin a independent manner.Synonyms: Importin subunit beta-1, Importin-90, KPNB1, Nuclear factor P97

Molecular Weight: 96 kDa

Gene ID: 3837

NCBI Accession: NP_002256

UniProt: Q14974

Pathways: Protein targeting to Nucleus