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VEGFR2/CD309 antibody (VEGF Receptor 2) (Extracellular Domain) (Biotin) Primary Antibody

VEGFR2 Reactivity: Human EIA, FACS, IHC (fro), IF, WB Host: Mouse Monoclonal 4 (20I6) Biotin
Catalog No. ABIN155178
$477.40
Plus shipping costs $45.00
50 μg
local_shipping Shipping to: United States
Available
  • Target
    VEGFR2/CD309 (VEGFR2)
    Binding Specificity
    • 40
    • 38
    • 27
    • 26
    • 22
    • 19
    • 17
    • 16
    • 12
    • 12
    • 9
    • 9
    • 9
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    Reactivity
    • 336
    • 215
    • 147
    • 17
    • 8
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 320
    • 64
    • 16
    • 2
    • 2
    • 1
    • 1
    Mouse
    Clonality
    • 305
    • 101
    Monoclonal
    Conjugate
    • 188
    • 32
    • 21
    • 15
    • 15
    • 13
    • 12
    • 11
    • 11
    • 10
    • 10
    • 10
    • 10
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This VEGFR2/CD309 antibody is conjugated to Biotin
    Application
    • 212
    • 157
    • 114
    • 101
    • 79
    • 67
    • 44
    • 26
    • 24
    • 15
    • 13
    • 13
    • 9
    • 8
    • 8
    • 4
    • 4
    • 2
    • 1
    Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
    Specificity
    The Unconjugated Monoclonal antibody will detect native Human VEGFR-2/KDR in ELISA experiments and on the surface of different Human cell types.
    Purification
    Affinity Chromatography on Protein G
    Immunogen
    Recombinant Human soluble extracellular KDR (D7) (110 kDa) protein (Cat.-No AR26018PUN)
    Clone
    4 (20I6)
    Isotype
    IgG1
  • Application Notes
    Flow cytometry: 2-5 μg/mL. Immunoflourescence. Immunohistochemistry on frozen sections. ELISA. Western blot.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Reconstitution
    Restore in sterile water to a concentration of 0.1-1.0 mg/mL
    Buffer
    PBS, 0.02 % Sodium Azide, BSA (50x)
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    VEGFR2/CD309 (VEGFR2)
    Alternative Name
    CD309 / VEGFR-2 / Flk-1 (VEGFR2 Antibody Abstract)
    Synonyms
    CD309, FLK1, VEGFR, VEGFR2, 6130401C07, Flk-1, Flk1, Krd-1, Ly73, VEGFR-2, sVEGFR-2, Vegfr-2, FLK-1, flk-1, vegfr-2, KDR, FLK/KDR, flk1, flk1b, kdrb, si:busm1-205d10.1, si:ch211-254j6.1, si:ch211-278f21.4, wu:fc31a09, fk52c05, flk, kdr, kdra, vegfr2, vegfr4, vegr2, wu:fk52c05, kinase insert domain receptor, kinase insert domain protein receptor, vascular endothelial growth factor receptor kdr-like, kinase insert domain receptor (a type III receptor tyrosine kinase), kinase insert domain receptor like, KDR, Kdr, LOC100136647, kdr, kdrl
    Background
    VEGF receptor 2 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.Synonyms: FLK1, KDR, Kinase NYK, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, VEGF Receptor 2, VEGFR2, Vascular endothelial growth factor receptor 2
    Gene ID
    3791
    NCBI Accession
    NP_002244
    UniProt
    P35968
    Pathways
    RTK Signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
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