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VEGFR2/CD309 antibody (AA 20-764)

VEGFR2 Reactivity: Human WB, ELISA, FACS, ICC Host: Mouse Monoclonal 4B4 unconjugated
Catalog No. ABIN969231
  • Target See all VEGFR2/CD309 (VEGFR2) Antibodies
    VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
    Binding Specificity
    • 37
    • 36
    • 27
    • 22
    • 20
    • 20
    • 16
    • 16
    • 14
    • 10
    • 9
    • 8
    • 8
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 20-764
    Reactivity
    • 307
    • 196
    • 145
    • 18
    • 9
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 309
    • 48
    • 9
    • 2
    • 1
    • 1
    • 1
    Mouse
    Clonality
    • 304
    • 67
    Monoclonal
    Conjugate
    • 163
    • 34
    • 21
    • 15
    • 13
    • 13
    • 11
    • 11
    • 11
    • 11
    • 11
    • 11
    • 6
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This VEGFR2/CD309 antibody is un-conjugated
    Application
    • 238
    • 135
    • 98
    • 80
    • 63
    • 34
    • 26
    • 23
    • 22
    • 13
    • 13
    • 12
    • 9
    • 7
    • 7
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
    Purification
    purified
    Immunogen
    Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.
    Clone
    4B4
    Isotype
    IgG1
    Top Product
    Discover our top product VEGFR2 Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Takahashi, Yamaguchi, Chida, Shibuya: "A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells." in: The EMBO journal, Vol. 20, Issue 11, pp. 2768-78, (2001) (PubMed).

  • Target
    VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
    Alternative Name
    KDR (VEGFR2 Products)
    Synonyms
    CD309 antibody, FLK1 antibody, VEGFR antibody, VEGFR2 antibody, 6130401C07 antibody, Flk-1 antibody, Flk1 antibody, Krd-1 antibody, Ly73 antibody, VEGFR-2 antibody, sVEGFR-2 antibody, Vegfr-2 antibody, FLK-1 antibody, flk-1 antibody, vegfr-2 antibody, KDR antibody, FLK/KDR antibody, flk1 antibody, flk1b antibody, kdrb antibody, si:busm1-205d10.1 antibody, si:ch211-254j6.1 antibody, si:ch211-278f21.4 antibody, wu:fc31a09 antibody, fk52c05 antibody, flk antibody, kdr antibody, kdra antibody, vegfr2 antibody, vegfr4 antibody, vegr2 antibody, wu:fk52c05 antibody, kinase insert domain receptor antibody, kinase insert domain protein receptor antibody, vascular endothelial growth factor receptor kdr-like antibody, kinase insert domain receptor (a type III receptor tyrosine kinase) antibody, kinase insert domain receptor like antibody, KDR antibody, Kdr antibody, LOC100136647 antibody, kdr antibody, kdrl antibody
    Background

    Description: KDR has also been designated as VEFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.

    Aliases: FLK1, CD309, VEGFR, VEGFR2

    Molecular Weight
    152 kDa
    Gene ID
    3791
    HGNC
    3791
    Pathways
    RTK Signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
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