CKMT1A antibody (AA 258-417)

Catalog No. ABIN1679244

This anti-CKMT1A antibody is a Rabbit Polyclonal antibody detecting CKMT1A in WB. Suitable for Human.

Quick Overview for CKMT1A antibody (AA 258-417) (ABIN1679244)

Target: CKMT1A (Creatine Kinase, Mitochondrial 1A (CKMT1A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CKMT1A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CKMT1A Antibody

Binding Specificity: AA 258-417

Sequence: FLIWVNEEDH TRVISMEKGG NMKRVFERFC RGLKEVERLI QERGWEFMWN ERLGYILTCP SNLGTGLRAG VHIKLPLLSK DSRFPKILEN LRLQKRGTGG VDTAATGGVF DISNLDRLGK SEVELVQLVI DGVNYLIDCE RRLERGQDIR IPTPVIHTKH

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 258-417 of human CKMT1A (NP_001015001.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CKMT1A

Target: CKMT1A (Creatine Kinase, Mitochondrial 1A (CKMT1A))

Alternative Name: CKMT1A

Background: Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80 % homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.,CKMT1A,CKMT1,U-MtCK,mia-CK,Signal Transduction,Kinase,CKMT1A

Molecular Weight: 47 kDa/50 kDa

Gene ID: 548596

UniProt: P12532