PLAA antibody (AA 536-795)

Catalog No. ABIN1682194

This Rabbit Polyclonal antibody specifically detects PLAA in WB. It exhibits reactivity toward Human.

Quick Overview for PLAA antibody (AA 536-795) (ABIN1682194)

Target: PLAA (Phospholipase A2-Activating Protein (PLAA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PLAA Antibody

Binding Specificity: AA 536-795

Sequence: PKKEAVTFDQ ANPTQILGKL KELNGTAPEE KKLTEDDLIL LEKILSLICN SSSEKPTVQQ LQILWKAINC PEDIVFPALD ILRLSIKHPS VNENFCNEKE GAQFSSHLIN LLNPKGKPAN QLLALRTFCN CFVGQAGQKL MMSQRESLMS HAIELKSGSN KNIHIALATL ALNYSVCFHK DHNIEGKAQC LSLISTILEV VQDLEATFRL LVALGTLISD DSNAVQLAKS LGVDSQIKKY SSVSEPAKVS ECCRFILNLL

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 536-795 of human PLAA (NP_001026859.1).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PLAA

Target: PLAA (Phospholipase A2-Activating Protein (PLAA))

Alternative Name: PLAA

Background: Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development (By similarity. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha- or lipopolysaccharide (LPS-dependent manner, and hence prostaglandin E2 biosynthesis.,PLAA,DOA1,PLA2P,PLAP,NDMSBA,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,PLAA

Molecular Weight: 87 kDa

Gene ID: 9373

UniProt: Q9Y263