TLN1 antibody (AA 1-220)

Catalog No. ABIN1683044

The Rabbit Polyclonal anti-TLN1 antibody has been validated for WB and IF. It is suitable to detect TLN1 in samples from Human.

Quick Overview for TLN1 antibody (AA 1-220) (ABIN1683044)

Target: TLN1 (Talin 1 (TLN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-TLN1 Antibody

Binding Specificity: AA 1-220

Sequence: MVALSLKISI GNVVKTMQFE PSTMVYDACR IIRERIPEAP AGPPSDFGLF LSDDDPKKGI WLEAGKALDY YMLRNGDTME YRKKQRPLKI RMLDGTVKTI MVDDSKTVTD MLMTICARIG ITNHDEYSLV RELMEEKKEE ITGTLRKDKT LLRDEKKMEK LKQKLHTDDE LNWLDHGRTL REQGVEEHET LLLRRKFFYS DQNVDSRDPV QLNLLYVQAR

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human TLN1 (NP_006280.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TLN1

Target: TLN1 (Talin 1 (TLN1))

Alternative Name: TLN1

Background: This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.,TLN1,ILWEQ,TLN,talin-1,Signal Transduction,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,Protein folding,Immunology & Inflammation,T Cell Receptor Signaling Pathway,TLN1

Molecular Weight: 269 kDa

Gene ID: 7094

UniProt: Q9Y490

Pathways: Cell-Cell Junction Organization, ER-Nucleus Signaling, Maintenance of Protein Location