UCMA antibody (AA 21-120) (AbBy Fluor® 488)

Catalog No. ABIN1694972

The Rabbit Polyclonal anti-UCMA antibody has been validated for WB. It is suitable to detect UCMA in samples from Human.

Quick Overview for UCMA antibody (AA 21-120) (AbBy Fluor® 488) (ABIN1694972)

Target: UCMA (Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UCMA antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB)

Product Details anti-UCMA Antibody (AbBy Fluor® 488)

Binding Specificity: AA 21-120

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human UCMA

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for UCMA

Target: UCMA (Upper Zone of Growth Plate and Cartilage Matrix Associated (UCMA))

Alternative Name: UCMA

Background:

Synonyms: C10orf49, Gla rich protein, Gla-rich protein, Grp, GRP, OTTMUSP00000011599, RP23-272I15.1, UCMA, Ucma-C, UCMA_HUMAN, Unique cartilage matrix associated protein, Unique cartilage matrix-associated protein C-terminal fragment, Upper zone of growth plate and cartilage matrix associated.

Background: UCMA is a 138 amino acid secreted protein that is highly expressed in resting chrondrocytes in developing long bones and is thought to function in the early phase of chrondrocyte differentiation. A furin-like protease processes UCMA into an N-terminal 37 amino acid peptide and a C-terminal 74 amino acid peptide, which is referred to as Unique cartilage matrix-associated protein C-terminal fragment (Ucma-C). Introduction of recombinant Ucma-C interferes with osteogenic differentiation of mesenchymal stem cells, MC3T3-E1 preosteoblasts and primary osteoblasts. This suggests that Ucma may be involved in the negative regulation of osteogenic differentiation of osteochondrogenic precursor cells at the cartilage-bone interface and in peripheral zones of fetal cartilage.

Gene ID: 221044