HDAC5 antibody (pSer498) (AbBy Fluor® 555)

Catalog No. ABIN1696954

This Rabbit Polyclonal antibody specifically detects HDAC5 in WB and IF (p). It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog and Chicken.

Quick Overview for HDAC5 antibody (pSer498) (AbBy Fluor® 555) (ABIN1696954)

Target: HDAC5 (Histone Deacetylase 5 (HDAC5))

Reactivity: Human, Mouse, Rat, Cow, Dog, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC5 antibody is conjugated to AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-HDAC5 Antibody (AbBy Fluor® 555)

Binding Specificity: pSer498

Cross-Reactivity: Cow, Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human HDAC5 around the phosphorylation site of Ser498

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HDAC5

Target: HDAC5 (Histone Deacetylase 5 (HDAC5))

Alternative Name: HDAC5

Background:

Synonyms: HDAC5Ser498, HDAC5S498, p-HDAC5Ser498, p-HDAC5S498, HD 5, HD5, HDAC 5, Histone deacetylase 5, KIAA0600, NY CO 9, Antigen NY CO 9, FLJ90614, HDAC5_HUMAN, Antigen NY-CO-9.

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Monocarboxylic Acid Catabolic Process