GCHFR antibody (AA 21-60) (Biotin)

Catalog No. ABIN1700812

This Rabbit Polyclonal antibody specifically detects GCHFR in ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Rat.

Quick Overview for GCHFR antibody (AA 21-60) (Biotin) (ABIN1700812)

Target: GCHFR (GTP Cyclohydrolase I Feedback Regulator (GCHFR))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCHFR antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-GCHFR Antibody (Biotin)

Binding Specificity: AA 21-60

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GCHFR

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for GCHFR

Target: GCHFR (GTP Cyclohydrolase I Feedback Regulator (GCHFR))

Alternative Name: GCHFR

Background:

Synonyms: GCHFR, GFRP, GFRP_HUMAN, GTP cyclohydrolase 1 feedback regulatory protein, GTP cyclohydrolase I feedback regulator, GTP cyclohydrolase I feedback regulatory protein, HsT16933, MGC138467, MGC138469, p35.

Background: GTP cyclohydrolase I feedback regulatory protein (GFRP) is encoded by the gene GCHFR. GFRP mediates feedback inhibition of GTP cyclohydrolase I activity by tetrahydrobiopterin. GFRP also acts as a mediator for the stimulatory effect of phenylalanine on enzyme activity. L-phenylalanine reverses this inhibition. The molecular weight of GFRP is approximately 9.5 kDa although cross-linking experiments have shown that GFRP is usually found as a homodimer or as a pentamer. 15q15.

Gene ID: 2644