CATSPER4 antibody (AA 101-200) (Cy3)

Catalog No. ABIN1701770

The Rabbit Polyclonal anti-CATSPER4 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect CATSPER4 in samples from Human.

Quick Overview for CATSPER4 antibody (AA 101-200) (Cy3) (ABIN1701770)

Target: CATSPER4 (Cation Channel, Sperm Associated 4 (CATSPER4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CATSPER4 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CATSPER4 Antibody (Cy3)

Binding Specificity: AA 101-200

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CATSPER4

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CATSPER4

Target: CATSPER4 (Cation Channel, Sperm Associated 4 (CATSPER4))

Alternative Name: CATSPER4

Background:

Synonyms: CTSR4_HUMAN, Cation channel sperm-associated protein 4, CatSper4, CatSper-4, cation channel, sperm-associated 4.

Background: CatSpers (cation channel, sperm associated proteins) are ion transport proteins located on the surface of sperm cells in the principal piece of the sperm tail. CatSpers are vital to sperm motility, fertilization and cAMP-mediated calcium influx in sperm. There are four CatSper proteins in mammalian sperm, namely CatSper (or CatSper1), CatSper2, CatSper3 and CatSper4. CatSper proteins contain a single, six-transmembrane-spanning segment and exhibit the voltage-dependent Ca2+ channel four-repeat structure. CatSper proteins are believed to assemble into a heterotetrameric complex, forming an alkalinization-activated Ca2+-selective channel. Mutations in any of the genes encoding CatSper family proteins can result in male infertility. CatSper3 plays an important role in the hyperactivated motility of sperm cells, a process that is required in the preparation of sperm for fertilization.

Gene ID: 378807

UniProt: Q7RTX7