Copa/Alpha Cop I (AA 451-550) antibody (Cy3)

Catalog No. ABIN1702444

This Rabbit Polyclonal antibody specifically detects in IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for Copa/Alpha Cop I (AA 451-550) antibody (Cy3) (ABIN1702444)

Target: Copa/Alpha Cop I

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Cy3

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details

Binding Specificity: AA 451-550

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human COPA/alpha COP I

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Copa/Alpha Cop I

Background:

Synonyms: Alpha coat protein, Alpha COP, Alpha COPI, AlphaCOP, Coatomer protein complex subunit alpha, Coatomer subunit alpha, COP A, COP I alpha, COPA, COPI alpha, FLJ26320, HEP COP, HEPCOP, Proxenin, Xenin, Xenopsin-related peptide, COPA_HUMAN.

Background: COPA (alpha-coat protein) is processed to produce Xenin. Xenin stimulates exocrine pancreatic secretion to affect small and large intestinal motility, and inhibits pentagastrin-stimulated secretion of acid. In the gut, Xenin interacts with the neurotensin receptor. Membrane and vesicular trafficking in the early secretory pathway are mediated by non-Clathrin COP (coat protein) I-coated vesicles. COPI-coated vesicles mediate retrograde transport from the Golgi back to the ER and intra-Golgi transport. The cytosolic precursor of the COPI coat, the heptameric coatomer complex, is composed of two subcomplexes. The first consists of the COPB, COPG, COPD and COPZ subunits (also known as b-, g-, d- and z-COP, respectively), which are distantly homologous to AP Clathrin adaptor subunits. The second consists of the COPA, b'-COP and COPE subunits (also known as a-COP, COPP and e-COP, respectively).

Gene ID: 1314