ITPA antibody (AA 1-100) (Cy5)

Catalog No. ABIN1703971

This Rabbit Polyclonal antibody specifically detects ITPA in WB, IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for ITPA antibody (AA 1-100) (Cy5) (ABIN1703971)

Target: ITPA (Inosine Triphosphatase (ITPA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITPA antibody is conjugated to Cy5

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-ITPA Antibody (Cy5)

Binding Specificity: AA 1-100

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Inosine triphosphate pyrophosphatase

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ITPA

Target: ITPA (Inosine Triphosphatase (ITPA))

Alternative Name: Inosine triphosphate pyrophosphatase

Background:

Synonyms: ITPase, C20orf37, dJ794I6.3, HLC14-06-P, Inosine triphosphatase nucleoside triphosphate pyrophosphatase, Inosine triphosphatase, inosine triphosphatase-A, Inosine triphosphate pyrophosphatase, Inosine triphosphate pyrophosphohydrolase, Itpa, ITPA_HUMAN, ITPase, My049, My049 protein, Non canonical purine NTP pyrophosphatase, Non standard purine NTP pyrophosphatase, NTPase, nucleoside triphosphate diphosphatase, Nucleoside triphosphate pyrophosphatase, OK/SW-cl.9, OTTHUMP00000030094, OTTHUMP00000160459, Putative oncogene protein hlc14-06-p.

Background: ITPase (inosine triphosphate pyrophosphatase) is also known as putative oncogene protein hlc14-06-p or ITPA (inosine triphosphatase (nucleoside triphosphate pyrophosphatase)) and is a 194 amino acid protein. ITPase is abundantly expressed in heart, liver, sex glands, thyroid and adrenal gland, and is localized to the cytoplasm in the cell. ITPase catalyzes the pyrophosphohydrolysis of both ITP (inosine triphosphate) and dITP (deoxyinosine triphosphate) to IMP (inosine monophosphate) and diphosphate. IMP can be used as a substrate for purine nucleotide pathways. IMP can be phosphorylated to ITP, and ITPase can regulate the concentration of ITP in the cell by converting ITP back to IMP. Defects in ITPase result in ITPase deficiency which is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.

Gene ID: 3704