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GMEB2 antibody (AA 101-200) (FITC)

The Rabbit Polyclonal anti-GMEB2 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect GMEB2 in samples from Mouse.
Catalog No. ABIN1709759

Quick Overview for GMEB2 antibody (AA 101-200) (FITC) (ABIN1709759)

Target

See all GMEB2 Antibodies
GMEB2 (Glucocorticoid Modulatory Element Binding Protein 2 (GMEB2))

Reactivity

  • 25
  • 14
  • 11
  • 2
  • 2
  • 2
  • 2
  • 1
Mouse

Host

  • 28
Rabbit

Clonality

  • 28
Polyclonal

Conjugate

  • 8
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This GMEB2 antibody is conjugated to FITC

Application

  • 19
  • 12
  • 12
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Binding Specificity

    • 14
    • 2
    • 1
    • 1
    AA 101-200

    Cross-Reactivity

    Mouse

    Predicted Reactivity

    Human,Rat,Dog,Cow,Sheep,Horse,Chicken,Rabbit

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human GMEB2

    Isotype

    IgG
  • Application Notes

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    GMEB2 (Glucocorticoid Modulatory Element Binding Protein 2 (GMEB2))

    Alternative Name

    GMEB2

    Background

    Synonyms: GMEB2, DNA binding protein p79P, DNA-binding protein p79P, Glucocorticoid modulatory element binding protein 2, Glucocorticoid modulatory element-binding protein 2, GMEB 2, GMEB-2, Gmeb2, GMEB2_HUMAN, KIAA1269, P79P, Parvovirus initiation factor p79, P p79, P79, RP4 663D7.1.

    Background: GMEB-2 is a DNA-binding protein that plays a crucial role modulating transcription upon activation by steroid hormones. GMEB-2 is ubiquitously expressed with preferential expression in developmentally important tissues, such as testis, bone marrow, placenta and fetal tissues. It localizes to the nucleus and cytoplasm and contains a SAND domain near its N-terminus and a C-terminal coiled coil structure. GMEB-2 functions as a homodimer or as a heterodimer with GMEB-1. The formed complex specifically binds to glucocorticoid modulatory elements (GME) in the promoter region of target genes and recruits the histone acetylase CREB binding protein (CBP) during glucocorticoid signaling. This acts to increase sensitivity to low concentrations of glucocorticoids. In addition, GMEB-2 functions as an auxiliary factor required for parvovirus replication.

    Gene ID

    26205
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