CUTC antibody (AA 201-273) (HRP)

Catalog No. ABIN1711271

The Rabbit Polyclonal anti-CUTC antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect CUTC in samples from Human.

Quick Overview for CUTC antibody (AA 201-273) (HRP) (ABIN1711271)

Target: CUTC (CutC Copper Transporter Homolog (CUTC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CUTC antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CUTC Antibody (HRP)

Binding Specificity: AA 201-273

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CUTC

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CUTC

Target: CUTC (CutC Copper Transporter Homolog (CUTC))

Alternative Name: CUTC

Background:

Synonyms: CGI 32, CGI32, Copper homeostasis protein cutC homolog, cutC, CutC copper transporter homolog E. coli, CUTC_HUMAN, RP11-483F11.3.

Background: Copper is an essential micronutrient used as a co-factor for several essential enzymes in all living organisms. Due to the high toxicity of copper, its metabolism is tightly regulated and defects in this regulation can cause Menkes (deficiency) or Wilson (accumulation) disease in various tissue. CUTC (cutC copper transporter homolog (E. coli)), also known as CGI-32, is a 273 amino acid protein belonging to the cutC family. CUTC is involved in copper homeostasis and is encoded by a gene located on human chromosome 10, which contains over 800 genes and 135 million nucleotides. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. Other chromosome 10 associated disorders include Cockayne syndrome, tetrahydrobiopterin deficiency and trisomy 10.

Gene ID: 51076

Pathways: Transition Metal Ion Homeostasis