Ggt5 Heavy Chain (AA 51-150) antibody (HRP)

Catalog No. ABIN1711889

The Rabbit Polyclonal anti- antibody has been validated for WB, ELISA, IHC (fro) and IHC (p). It is suitable to detect in samples from Human.

Quick Overview for Ggt5 Heavy Chain (AA 51-150) antibody (HRP) (ABIN1711889)

Target: Ggt5 Heavy Chain

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Binding Specificity: AA 51-150

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Gamma-glutamyltransferase 5 heavy chain

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Ggt5 Heavy Chain

Background:

Synonyms: Gamma glutamyl transpeptidase related enzyme, Gamma glutamyltranspeptidase 5, Gamma-glutamyl transpeptidase-related enzyme, Gamma-glutamyltransferase 5 heavy chain, Gamma-glutamyltransferase-like activity 1, Gamma-glutamyltranspeptidase 5, GGT 5, GGT REL, GGT-rel, GGT5, GGT5_HUMAN, DKFZP566O011, GGTLA1, Glutathione hydrolase 5, Leukotriene-C4 hydrolase, Gamma-glutamyltransferase 5 heavy chain.

Background: g-glutamyltranspeptidase (GGT) acts as a glutathionase and catalyzes the transfer of the glutamyl moiety of Glutathione to a variety of amino acids and dipeptide acceptors. This enzyme is located on the outer surface of the cell membrane and is widely distributed in mammalian tissues involved in absorption and secretion. In humans, hepatic GGT activity is elevated in some liver diseases. GGT1 is released into the bloodstream after liver damage and an elevated level of the enzyme may be a useful early sign of hepatocellular carcinoma. GGT5 converts Leukotriene C4 to Leukotriene D4, it does not, however, convert synthetic substrates that are commonly used to assay GGT. In human serum and tissues there is a marked heterogeneity in GGT, but this heterogeneity can be attributed to different glycosylation of the same peptide rather than to the products of different genes.

Gene ID: 2687

UniProt: P36269