GLUD2 antibody (PE-Cy7)

Catalog No. ABIN1713285

This anti-GLUD2 antibody is a Rabbit Polyclonal antibody detecting GLUD2 in WB. Suitable for Human, Mouse, Rat, Cow and Dog.

Quick Overview for GLUD2 antibody (PE-Cy7) (ABIN1713285)

Target: GLUD2 (Glutamate Dehydrogenase 2 (GLUD2))

Reactivity: Human, Mouse, Rat, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLUD2 antibody is conjugated to PE-Cy7

Application: Western Blotting (WB)

Product Details anti-GLUD2 Antibody (PE-Cy7)

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GLUD2

Isotype: IgG

Application Details

Application Notes: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GLUD2

Target: GLUD2 (Glutamate Dehydrogenase 2 (GLUD2))

Alternative Name: GLUD2

Background:

Synonyms: GDH 2, GDH, GDH2, GLUDP1, Glutamate dehydrogenase 2, Glutamate dehydrogenase 2 mitochondrial, Glutamate dehydrogenase pseudogene 1.

Background: GLUD2 is both mitochondrial matrix enzymes belonging to the Glu/Leu/Phe/Val dehydrogenases family. Exisiting as homohexamers, GLUD1 catalyzes the oxidative deamination of glutamate to ?ketoglutarate and ammonia while GLUD2 is involved in the recycling of glutamate during neurotransmission. GLUD1 is critical for regulating amino acid induced insulin secretion and is allosterically activated by ADP and inhibited by GTP and ATP. Mutations in the gene encoding GLUD1 causes hyperinsulinism-hyperammonemia syndrome (HHS), which is an inherited condition characterized by high insulin and ammonia levels in the blood. GLUD1 may also be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. GLUD2 is expressed in testis and retina, with lower levels found in brain.

Gene ID: 2747

Pathways: Synaptic Membrane