DUSP5 antibody (AA 221-320)

Catalog No. ABIN1713770

The Rabbit Polyclonal anti-DUSP5 antibody has been validated for WB, ELISA, IF (cc), IF (p), ICC, IHC (fro) and IHC (p). It is suitable to detect DUSP5 in samples from Human and Mouse. There is 1 publication available.

Quick Overview for DUSP5 antibody (AA 221-320) (ABIN1713770)

Target: DUSP5 (Dual Specificity Phosphatase 5 (DUSP5))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-DUSP5 Antibody

Binding Specificity: AA 221-320

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DUSP5

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-DUSP5 antibody (ABIN1713770)

Cai, Chen, Han, He, Chen, Chen, Yang, Wu, Zeng, Zou, Liang, Dai, Jiang, Zhong: "Down-regulation of dual-specificity phosphatase 5 predicts poor prognosis of patients with prostate cancer." in: International journal of clinical and experimental medicine, Vol. 8, Issue 3, pp. 4186-94, (2015) (PubMed).

Target Details for DUSP5

Target: DUSP5 (Dual Specificity Phosphatase 5 (DUSP5))

Alternative Name: DUSP5

Background:

Synonyms: Dual specicity protein phosphatase 5, Dual specicity protein phosphatase hVH 3, Dual specicity protein phosphatase hVH3, DUSP 5, DUSP, HVH 3, HVH3, Serine/threonine specic protein phosphatase, VH 3, VH1 like phosphatase 3, VH3, DUS5_HUMAN.

Background: Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. The members of the dual-specificity phosphatase protein family include MKP-1/CL100 (3CH134), MKP-2, MKP-3, MKP-4, MKP-5, MKP-6, MKP-7, MKP-X, VHR, VHY, PAC1, hVH-3 (B23), hVH-5, PYST2, DUSP1, DUSP5, DUSP8, PIR1 and SKRP1. DUSP5 is a nuclear phosphoprotein that displays phosphatase activity toward several different substrates. It shows the highest relative activity toward ERK1.

Gene ID: 1847