KAT5 antibody (AA 51-150)

Catalog No. ABIN1713854

The Rabbit Polyclonal anti-KAT5 antibody has been validated for WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) and ICC. It is suitable to detect KAT5 in samples from Mouse and Rat.

Quick Overview for KAT5 antibody (AA 51-150) (ABIN1713854)

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KAT5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Product Details anti-KAT5 Antibody

Binding Specificity: AA 51-150

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KAT5 / Tip60

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for KAT5

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Alternative Name: KAT5 / Tip60

Background:

Synonyms: 60 kDa Tat interactive protein, 60 kDa Tat-interactive protein, cPLA2 interacting protein, cPLA2-interacting protein, cPLA2, cPLA2 interacting protein, ESA1, Histone acetyltransferase HTATIP, Histone acetyltransferase KAT5, HIV 1 Tat interactive protein, HIV 1 Tat interactive protein, 60 kDa, HIV-1 Tat interactive protein, HTATIP, HTATIP1, Klysine acetyltransferase 5, K-acetyltransferase 5, KAT5, KAT5_HUMAN, Lysine acetyltransferase 5, PLIP, Tat interacting protein, 60 kDa, TIP, Tip60.

Background: MOZ (monocytic leukemia zinc finger protein) is a chromatin-associated histone acetyltransferase (HAT) that regulates chromatin remodeling and transcription. The MOZ gene was initially isolated as a consequence of two variant translocations that were identified in a distinct subtype of acute myeloid leukemias and resulted in the formation of MOZ fusion proteins. These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional coactivator protein TIF2/GRIP1 or CBP, and lead to enhanced transcriptional activation by a mechanism involving aberrant histone acetylation. Additional MOZ related proteins, including MORF (MOZ related factor) and TIP60 (TAT interacting proteins 60), share significant similarities with MOZ including the putuative HAT domain. MORF also contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at the C terminus, suggesting that MORF has both HAT activity and contributes to the regulation of transcriptional activation. TIP60 was originally identified as a coactivator for the HIV TAT protein and also functions as a nuclear hormone receptor coactivator that enhances ligand dependent steroid receptor-mediated transactivation involving the androgen, estrogen and progesterone receptors.

UniProt: Q92993

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway