HDAC5 antibody (pSer498)

Catalog No. ABIN1714080

This anti-HDAC5 antibody is a Rabbit Polyclonal antibody detecting HDAC5 in WB, IHC (p) and IF (p). Suitable for Human, Mouse, Rat, Cow, Dog and Chicken.

Quick Overview for HDAC5 antibody (pSer498) (ABIN1714080)

Target: HDAC5 (Histone Deacetylase 5 (HDAC5))

Reactivity: Human, Mouse, Rat, Cow, Dog, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-HDAC5 Antibody

Binding Specificity: pSer498

Cross-Reactivity: Cow, Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human HDAC5 around the phosphorylation site of Ser498

Isotype: IgG

Application Details

Application Notes: WB (1:100-500),IHC-P (1:100-500),IF (p) (1:100-500)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for HDAC5

Target: HDAC5 (Histone Deacetylase 5 (HDAC5))

Alternative Name: HDAC5

Background:

Synonyms: HDAC5Ser498, HDAC5S498, p-HDAC5Ser498, p-HDAC5S498, HD 5, HD5, HDAC 5, Histone deacetylase 5, KIAA0600, NY CO 9, Antigen NY CO 9, FLJ90614, HDAC5_HUMAN, Antigen NY-CO-9.

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Monocarboxylic Acid Catabolic Process