AQP2 antibody (pSer256)

Catalog No. ABIN1714244

The Rabbit Polyclonal anti-AQP2 antibody has been validated for WB, IF (p) and IHC (p). It is suitable to detect AQP2 in samples from Human, Rat and Mouse.

Quick Overview for AQP2 antibody (pSer256) (ABIN1714244)

Target: AQP2 (Aquaporin 2 (Collecting Duct) (AQP2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AQP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-AQP2 Antibody

Binding Specificity: pSer256

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human AQP2 around the phosphorylation site of Ser256

Isotype: IgG

Application Details

Application Notes: WB: (1:100-1000), IHC-P: (1:100-500), IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for AQP2

Target: AQP2 (Aquaporin 2 (Collecting Duct) (AQP2))

Alternative Name: Aqp2

Background:

Synonyms: Aquaporin 2 phospho S256, Aquaporin 2 phospho Ser256, p-Aquaporin 2 phospho S256, p-Aquaporin 2 S256, ADH water channel, AQP 2, AQP CD, AQP2, AQPCD, Aquaporin 2 collecting duct, Aquaporin CD, Aquaporin2, Aquaporine 2, Collecting duct water channel protein, MGC34501, Water channel protein for renal collecting duct, WCH CD, WCHCD, AQP2_HUMAN.

Background: Aquaporins (AQPs) are a large family of integral membrane water transport channel proteins that facilitate the transport of water through the cell membrane. This function is conserved in animals, plants and bacteria. Many isoforms of aquaporin have been identified in mammals, designated AQP0 through AQP10. Aquaporins are widely distributed and it is not uncommon for more than one type of AQP to be present in the same cell. Although most aquaporins are only permeable to water, AQP3, AQP7, AQP9 and one of the two AQP10 transcripts are also permeable to urea and glycerol. AQP2 is the only water channel that is activated by vasopressin to enhance water reabsorption in the kidney collecting duct. Aquaporins are involved in renal water absorption, generation of pulmonary secretions, lacrimation, and the secretion and reabsorption of cerebrospinal fluid and aqueous humor.

Gene ID: 359

Pathways: Response to Water Deprivation